Thu. Jun 4th, 2020

Hairgrowth Blog

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Adipose-Derived Stem Cell Constituent Extract

It has been a while since I wrote a post related to adipose-derived stem cells (ADSCs) and hair growth. Adipose cells are also called fat cells.

Adipose‐Derived Stem Cell Constituent Extract

A potentially groundbreaking new study from South Korea was published yesterday. Thanks to Chris and Joe who both e-mailed me with links. This study concluded that adipose‐derived stem cell constituent extract (ADSC‐CE) helps hair regrowth in patients with androgenetic alopecia.

Adipose-derived stem cell constituent extract (ADSC‐CE) treatment increased hair count and hair thickness in the study. © 2020 Tak/Lee/Cho/Kim — Stem Cells Translational Medicine, published by Wiley Periodicals, Inc. on behalf of AlphaMed Press.

According to the authors, this is the first time that ADSC‐CE and its benefits on hair growth have been demonstrated via a a randomized, double‐blind, vehicle‐controlled clinical trial. Many other past studies have shown the benefits of ADSC (often via interadermal injections) on male and female pattern hair loss sufferers.

This latest study was widely covered in the media, including by the Daily Mail and New Atlas. The trial was conducted at Busan (Pusan) National University Yangsan Hospital. It was completed in 2016, so I am not sure why results were delayed till 2020. The study was published in the journal Stem Cells Translational Medicine. The famous Dr. Anthony Atala is editor-in-chief of  this journal. He is quoted as saying that this treatment offered hope to hair loss sufferers.

ADSC-CE Before and After Hair Growth.
ADSC-CE hair growth photo at 8 weeks and 16 weeks. One of the four results presented in the study.

Hair counts (+28.1%) and hair diameter (+14.2%) both increased substantially in 34 patients who completed the study. Original patient enrollment was 29 men and nine women. Encouragingly, these results persisted 16 weeks post treatment, with no major side effects. The treatment entailed twice‐daily self‐application of an ADSC‐CE topical solution all over the scalp.

The authors assumed that ADSC‐CE is likely to penetrate scalp tissue more than existing products that are manufactured using conditioned media (ADSC‐CM).

Adipose (Fat) Cells and Hair Growth

A lot evidence on the benefits of fat cell injections upon hair has been accumulating over the past decade. Even as far back as 1954, there was a study published suggesting a connection between scalp thickness, fat loss and balding.

I have written around 10 posts in the past that cover ADSC and closely related subjects, although none in the past couple of years.

For example:

  • See my past post on Stromal Vascular Fraction (SVF) enhanced adipose transplantation and the STRAAND clinical trials.
  • And on Advanced adipose-derived stem cell protein extract (AAPE).
  • Also see my past posts on Kerastem and the company’s STYLE clinical trials.
  • I have also discussed important work from Dr. Valerie Horsley’s lab regarding adipocytes and their essential role in  hair follicle regeneration. Last year, I also discussed fat layer loss and tightness in balding scalps.

The post Adipose-Derived Stem Cell Constituent Extract appeared first on Hair Loss Cure 2020.